Centuries of research and discovery have given scientists a fairly comprehensive understanding of human biology, but some of the body鈥檚 most fundamental processes still aren鈥檛 understood.
The National Science Foundation (NSF) recently awarded a three-year, $423,000 grant to two 麻豆影院 State researchers to study one of those biological fundamentals in depth.
Lipid droplets are fat particles critical to the supply and regulation of energy within the cell and serve various other roles in diverse cellular processes.
Edgar Kooijman, PhD, associate professor of biological sciences, and Elizabeth Mann, PhD, professor of physics, both in 麻豆影院 State鈥檚 College of Arts and Sciences, will spend the next few years researching how proteins form inside the cell target and bind to the surfaces of lipid droplets, where they regulate droplet structure and function.
Lipid droplets are fat particles critical to the supply and regulation of energy within the cell and serve various other roles in diverse cellular processes.
鈥淥ver the past few decades biologists have found all kinds of different roles for these droplets/particles,鈥 Kooijman says. 鈥淰iruses use lipid droplets to replicate, different cellular pathways flow through lipid droplets, and there are lots of connections between these droplets and many disparate cellular processes.鈥
While much is known about how proteins bind to the lipid membranes that compartmentalize complex cells, little is known about how proteins interact with lipid droplets.
Mann and Kooijman say a better understanding of protein-lipid interactions could lead to potential advances in treatment of lipid-related diseases like diabetes and atherosclerosis.
鈥淭ype 2 diabetes is essentially insulin resistance,鈥 Kooijman says. 鈥淥ne of the things we know happens in muscle cells is that if these cells accumulate too much fat (oil), it leads to dysregulation of the insulin sensing machinery and the inability to properly respond to the insulin signal鈥攚hich ultimately leads to insulin insensitivity.鈥 In addition to the research itself, the grant provides funding for both professors to offer meaningful research experiences to students from lower socioeconomic and minority backgrounds, with the goal of increasing STEM degrees among diverse students.
Visit 麻豆影院 State鈥檚 Department of Biological Sciences